Enhance The Immune System

Story at a glance

Immune System

The immune system is an incomprehensibly complex defense network of trillions of cells, multiple organs, and proteins and is located by virtue of its cells anywhere in the body where there is a threat to the survival of the organism. This includes the skin, bone marrow, the thymus gland, lymphatic vessels, lymph nodes, gastrointestinal tract, the spleen, and mucous membranes that line cavities and all the openings to the body from the outside. The “soldier” cells produced in the bone marrow include neutrophils, lymphocytes, eosinophils, basophils, and monocytes. They communicate with each other by producing chemical products, called cytokines that most often have a dual role of influencing the activity of other immune cells, like recruiting them or inactivating them, as well as, having a direct effect on pathogens and CFCs. Moreover, cytokines play a major role in the febrile response, which is an integral aspect of the acute inflammatory response. Fever increases “lymphocyte trafficking” (movement), increases the number being produced, and improves their functioning and speed of movement, thereby improving the overall immune surveillance process. Fever also modifies the cells that line vessels (endothelial cells) to allow easier migration of cells and those that line the lymph nodes and other lymphatic organs, thus improving the immune response. Research has shown that the use of drugs to lower fever (antipyretic) can increase mortality by 5% in influenza.

Compromised Immune System

If the immune system is optimally functioning, CFCs cannot grow or spread so having developed a tumor means that the immune system has been out of balance and/or overwhelmed to some degree. However, the vast amounts of toxins in the air, water, food, environment, and EMF continually damage cells requiring them to adapt, and when the accumulated damage affects enough mitochondria, the adaptation is CFCs. Since the immune system is exquisitely sensitive to EMF so now that we have 5G, everyone will have to do as much as possible to avoid exposure and live and eat healthy.

Tumor Microenvironment (TME)

As the CFCs progress, they utilize many strategies to evade the immune system. CFCs interact with their environment consisting of fibroblasts that produce the supportive tissue (stroma) and immune cells that control tumor growth and invasion by means of chemicals, called cytokines and interleukins, many of which are pro-inflammatory or immune-suppressing.

In many solid tumors, the stroma can comprise up to 90% of the tumor mass and consists of both cellular and noncellular components, including collagen, fibroblasts, and mesenchymal (stem) stromal cells that provide structure and remodeling. This remodeled and now activated stromal tissue is known as desmoplasia or fibrosis (scar tissue), which increases the mass and stiffness, to form an impenetrable shell. The immune cells found in the TME include macrophages, polymorphonuclear cells, mast cells, natural killer cells, dendritic cells (DCs), T and B lymphocytes, and, as stated non-immune cells such as endothelial cells and stromal cells.

The immune cells of a tumor are fundamental in determining the tumor’s fate, including its invasion and ability to spread (metastasize). This large variety of immune cells infiltrate tumors, and their composition and organization within the TME are closely associated with the clinical outcome of CFC patients. The type and function of each are intimately linked to their inherent functions as well as the molecules they produce (e.g., cytokines or inhibitory ligands). Then there are other immune cells, such as tumor-promoting M2 macrophages and immature granulocytic and monocytic cells, called myeloid-derived suppressor cells (MDSCs) that can favor tumor growth and progression through the induction of stromal cell proliferation, new blood vessels growth, and extracellular matrix (ECM) progression, and finally, the ability of the cells to migrate to other sites in the body.

Additionally, since CFCs ferment glucose, they produce large amounts of lactic acid and since the blood vessels are weak and chaotic, the blood supply to parts of the tumor often gets cut off resulting in areas with little oxygen (hypoxia). This biochemical “soup” around the tumor, called the tumor microenvironment (TME) also includes vascular cells recruited by the tumor to support its progression, and fibroblasts that secrete a variety of active factors to regulate tumor occurrence, development, metastasis, resistance, and remodel the extracellular matrix (ECM). This highly acidic and hypoxic (lack of oxygen) TME causes many of these cells to “switch sides” in order to support the tumor’s growth, weaken further the immune system, and protect the tumor from immune invasion.

The cytotoxic CD8+ T cells must be primed and educated by antigen-presenting cells such as DCs and macrophages and although these interactions have always been thought to take place in lymph nodes, it is now clear that they can also occur within, or next to, the tumor, in what is now called tertiary lymphoid structures. The regulatory CD4+ T lymphocytes (Tregs), directly secrete immunosuppressive molecules (e.g., IL-10, adenosine) that directly turn off the cytotoxic ability of CD8+ cells and DC or macrophages.

M1 macrophages produce free radicals and proinflammatory cytokines (cellular chemicals) such as Interferon (IFN)-γ, tumor necrosis factor (TNF)-α, Interleukin (IL)-2, and IL-1β, each of which plays critical roles in killing tumor cells. Whereas M2 macrophages produce anti-inflammatory cytokines such as IL-10 and tumor growth factor (TGF)-β, which promote tumor growth and progression. These M2 macrophages also induce new blood vessel growth (angiogenesis), as well as release growth factors and invasive secretions by a group of enzymes called matrix metalloproteinases (MMPs). The TME is such an environment that causes the M1 to become M2 macrophages. In fact, the mere discovery of TAMs in the TME indicates a poor prognosis.

Another consequence of the TME on the immune cells known as T4 (CD4) is that, CD4 can become T helper cells, T17 cells, and Tregs. T regulatory (Tregs) cells are CD4 cells that dampen the effectiveness of activated CD8+ cells (cytotoxic T cells). This is a necessary function of the immune system to ensure that an immune response does not go too far and damage healthy cells. This is exploited by CFCs when they produce cytokines that increase the number of Tregs. Then, the cytotoxic T cells are effectively disabled.

Furthermore, in many CFCs, the number of tumor associated neutrophils (TANs) also correlates with a poor prognosis and the neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood can be used to evaluate progress in therapy. In several studies, it has been found that a neutrophil greater than lymphocyte ratio of (NLR) > 1.67 was associated with an increased risk of breast and other CFC locations.

Therefore, the challenge is to modify the TME to reverse the adverse changes that have occurred to the immune cells. Of course, a cleansing and healthy lifestyle as described in “Stop Making Cancer” must be adhered to strictly, but in addition, there are a few interventions that have been found to be effective, and the results published in peer-reviewed journals.

Conventional oncology has developed so-called onco-immunology therapies with the intent to block immune suppressing processes and artificially direct the immune system to go after CFCs. While there has been some success in treating CFCs with these therapies, the effects are usually not lived and eventually stop working as the CFCs develop “acquired resistance”. These condensational therapies are called “checkpoint inhibitors” because certain tumor cells acquire the ability to bind to T-cells and block them from killing the tumor cells. So, these substances block that from occurring, by either binding to the T-cell or the receptor on the CFC so that the T-cell is not inhibited and can eliminate the CFCs.

In 1984, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) was discovered to block T lymphocytes from doing their job of killing CFCs and by 1995 two teams of researchers discovered independently that they could produce a monoclonal antibody (Mab) to block CTLA-4.

The next stage in this emerging field was the discovery of programmed death receptors (PD1) and programmed death receptor ligands (PDL1). The PD-1 receptor on the T cell is bound by the PDL-1 ligand on the T cell, thereby inactivating it as a defensive tactic. So, blocking either one would prevent the interaction from occurring and the T-cell would be able to work.

There have been problems, such as if the tumor is not surrounded by activated T cells (“cold” tumor), then it will have no effect, but it has been found that some drugs can cause the tumors to change into “hot” tumors by stimulating the T cells to surround the tumor ready to “fight”. One of these medicines is Ivermectin. In spite of this, the results are merely a few months longer survival.

However, there are several substances aside from lifestyle changes, including meditation that can modify the TME so that the deleterious changes that have occurred in the immune cell function in the TME can be reversed.

The onco-immunology that we employ does not interfere with natural processes or try to command the immune system in a certain direction but rather reverses the negative effects induced by the TME and allows the immune system to wake up naturally.

Some of the agents we use:

  1. IL-2
  2. GcMAF
  3. TA1
  4. Methionine Enkephalin
  5. Systemic Hyperthermia

Meditation and the Immune System

The effect of meditation on the immune system has been studied extensively and published in peer-reviewed journals. Meditation consists of several different forms, but the fundamental is to turn off the mind so that one can be present in the here and now.

Thinking is an involuntary process; hence the content is not under control. Everyone experiences a kaleidoscope of thoughts all day and most of the night. Only during deep sleep (delta wave) does thinking cease. Dreams are associated with theta waves and are very similar to the experience one has when engaged in a long repetitive movement, like running or biking where thoughts are seen but not really attended to or analyzed.

Approximately, 90% of the mind is subconscious hence it is not available to our conscious mind, and psychologists have found that 80% of human thoughts are negative. The problem is that the immune system is the “shadow of the mind”, hence all negative thoughts have a direct suppressive effect on the immune system.

Published studies on the measurable effects of meditation on the immune system have shown that once someone turns off the mind, it is like taking off the brakes that are holding the immune system down. There is a significant increase in natural killer (NK) cells and polarization towards a Th1 functioning system (instead of Th2), which is necessary to eliminate CFCs. Furthermore, higher CD3+CD4-CD8+ lymphocytes (activated T8 cells) and B lymphocytes, whereas the opposite was found with non-meditators.

Therefore, by developing a consistent frequency of meditation with achievable goals, like two minutes five times per day, one can develop the ability to turn off the mind when necessary to avoid negative feelings and thoughts but also on a regular schedule throughout the day allows for temporary boosts in the immune system.

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